1 [        .         .         .         .         :         .         .         .         .         1         .         .         .         .         :         .         .         .         .         2         .         .         .         .         :         .         .         .         .         3         .         .         .         .         :         .         .         .         .         4         .         .         .         .         :         .         .         .         .         5         .         .         .         .         :         .         .         .         .         6         .         .         .         .         :         .         .         .         .         7         .         .         .         .         :         .         .         .         .         8         .         .         .         .         :         .         .         .         .         9         .         .         .         .         :         .         .         .         .         0         .         .         .         .         :         .         .         .         .         1         .         .         .         .         :         .         .         .         .         2         .         .         .         .         :         .         .         .         .         3         .         .         .    ] 1335
1 PTH_0706      100.0%      -------MKYADLIHFEPVETIVQLREADAKSRAGELV----KTYVISERMAEQITEVVFPQLQYDHPQDNKG--LLIVGNYGTGKSHLMSVLSAIAEYP------DLATEIRHPAVAKKSEVIAGKFKVIRTE------------IGSTTMSLR------NIICAELEEQLANLGVQYRFPEADKVTNNKDPFIEVMTAFQEVYPDHGLLLVVDELLDY---LRTRKDQELILDLNFLREIGEVCRLTRFRFMAGVQ----------------EAIFDSPRFQFVAETLRRVK--DRFEQIR---IVREDIAYVVAQRLLRK-DDRQKALIREHLQRF---TRLYGTLAER--MDEFVALFPVHPAYLETFERVY-----VAEKREVLKTISAAMKKLLDKEVPETAPGLIAYDSYWQNLKDNPSFRSDPDIREVIEKSQVLENRVQQAFTRPQYKPVAFRIIHALSVHRLTTGDIYAPIGVTAQELRDDLCLYLPLPEEDAEFLKTTIESILREILRTV-----SGQFI--SFNQDNGQYYLDL-KKDIDFDSLIEQKAETL----TPNQLDRYYFKALARAMECPEATYVPNFQ---IWEHEIEWREKKATRLGYLFFGAPNERSTAHPPRDFYLYFLQP---FDPPAFEDE----KKPDEVFFRLVQRDEDFDRALKLFASASEMASTASKGTRQVYENKANDQLKKIV--EWLRNNIATAYE----VTYRGATKKFVEWVKHSANPHASVRDLVNLVGSSCLAPYFRELAPEYPIFAILVTIKNRPQAAQEAIKWILGSIRTRPGAAVLDALELLDGDKL-RPQNSRYA--KHILGQLDKKGPGQVLNRGEIIADFRGVEFEPRFRLEPEWVVVILASLIYSGDVTLSMPGKKIDASNLEELGKVPLEELIKFKHIERPKDLPLGPLQAL---FEFLGLPPGLI-VNQSTREEGVRQLQEAVDKLLERTAQAQQAIQQELSL--WGISLFDQKKKTGLRDELASFKGFLESLRVFNTPGKLKNFRYSERDINKQKAYLATLKRVEELAGLAKEIMPLLSYLSTAEAVLPADAGWTTKARERREELKGKLSGLDEASVPDLRRELVQVLLELKNSYIEAYLEAHTKARLNASLDQKKSGLLKDERLSKLSRLAGIELMPRAQLTDFQNRLAELKTCFSLTRENLGKTPICPHCNYRPAQEQIKLSAEAALRQLEEDLERLYQDWEKTLVANLEDPTVKENIYLLKPEQQKALEQVIKEQQLPYTVDASFVKAVQEALSGMEKVSVTAADLKKALAQGGTPCTVSELKQRFEDYIQSLTRGRDPQKVRIVLE     
2 Thebr_0951     43.0%      -------MRYGELIQYEPIETVIKLKDADKIDEAKRLV----KSFVVSEGMADSIINICIPQLQFDETIDNKG--IFIVGNYGTGKSHLMSVISAVAENK------EMLDYISHEELKKEMGKIAGKFKVLRFD------------IGAVNTPLR------NIITKEIEKDLARYGIEFYFPPIDKVTNNKEAFMEMMSKFEDKFPDKGYLIVVDELLDF---LKARKEQELIRDLTFLREIGEITKSTRLRFMTGVQ----------------ETLFDNPAFNAVAQTVLKMK--DRFEQLI---IKREDISYVVSQRLLKK-NDRQKAWIRSHLEKF---SPLYKSISSR--IEEFVELYPIHPMFIEVFEKMF-----IVEKREVLKTISHLMRELLDKDVPEDEPGIISYDSYWKFLRDNPSLRAEPDIKRVVDKSVVVEDLIEHSFTRPQYKDAALRIVHALSVHRFTTGDIHTSVGITVENIKDDLCLYIKMPEIEEDFLITTIETIMKEIMKTL-----SWQYI--SYNPDNQQYYLDMVREGINYDAKIQEKAELL----SDDTFNRYYFDLLIKVLDWNATLKQKNMR---IWEYSLIWNEKNVKRYGYLFMGYPDERSTAQPPRDFYIYFLPP---FVEANYNKKYILNGKEDEVFFEFINADEEIIEKIKKYAAAMELSELSSSDQKKIYEDKANGFQKDIT--KWIRDNVSKCFN----VSYKGETQSIIYWLKGKTANYDTIKSYIDEAASSCLSLYFSEKYSEYPTFYTKITEANLNEVFKSAMNYLAGK-KTETGKKVLQSFDLILGDDI-VPENSKYA--NYFLNELYKLPPGKVLNREDIIENVNGEDIDKRFKLEVQWVVLLLCALVYSGDIILRIKNKVYDATTIDSLANMNVGELVDFDSFERPRDIPVRELKTL---FTLLGLPSGLVNASLSKPEEAIRQMVSRSEELAKKVVTVNQFVVSNKTI--WSKPVFDEFEIKNYKDLLNNFRDFLDSLKAFNTPGKLRNFKYAEEELKEKFKTLETVKKIEKIIDFKNEVEELVKYLSSAEQQLPEEIELKQNINAMKNEVERFTKEIDNKESEDIKR-LTRELEELKIEYIDLYLEYHKKHRLDYNGDERKKKIMASDLFNNLKKLKDVGIFPVNKFDEIEKVLASLKTCYNFGKENIKTEVLCPNCGYSIKSGEVPVFGK--LDEIEDKIENLYKEWTKILLDNIEDPMIQERMEILNKDQQKVIRDFLNKKELPEKVDNLFVSAVKDLIAGLEKVEIEINEFISAITYDG-PVTVDEFKKRFLENVDFLIKGKDKDKVRIIIK     
3 Teth39_0926    43.0%      -------MRYGELIQYEPIETVIKLKDADKIDEAKRLV----KSFVVSEGMADSIINICIPQLQFDETIDNKG--IFIVGNYGTGKSHLMSVISAVAENK------EMLDYISHEELKKEMGKIAGKFKVLRFD------------IGAVNTPLR------NIITKEIEKDLARYGIEFYFPPIDKVTNNKEAFMEMMSKFEDKFPDKGYLIVVDELLDF---LKARKEQELIRDLTFLREIGEITKSTRLRFMTGVQ----------------ETLFDNPAFNAVAQTVLKMK--DRFEQLI---IKREDISYVVSQRLLKK-NDRQKAWIRSHLEKF---SPLYKSISSR--IEEFVELYPIHPMFIEVFEKMF-----IVEKREVLKTISHLMRELLDKDVPEDEPGIISYDSYWKFLRDNPSLRAEPDIKRVVDKSVVVEDLIEHSFTRPQYKDAALRIVHALSVHRFTTGDIHTSVGITVENIKDDLCLYIKMPEIEEDFLITTIETIMKEIMKTL-----SWQYI--SYNPDNQQYYLDMVREGINYDAKIQEKAELL----SDDTFNRYYFDLLIKVLDWNATLKQKNMR---IWEYSLIWNEKNVKRYGYLFMGYPDERSTAQPPRDFYIYFLPP---FVEANYNKKYILNGKEDEVFFEFINADEEIIEKIKKYAAAMELSELSSSDQKKIYEDKANGFQKDIT--KWIRDNVSKCFN----VSYKGETQSIIYWLKGKTANYDTIKSYIDEAASSCLSLYFSEKYSEYPTFYTKITEANLNEVFKSAMNYLAGK-KTETGKKVLQSFDLILGDDI-VPENSKYA--NYFLNELYKLPPGKVLNREDIIENVNGEDIDKRFKLEVQWVVLLLCALVYSGDIILRIKNKVYDATTIDSLANMNVGELVDFDSFERPRDIPVRELKTL---FTLLGLPSGLVNASLSKPEEAIRQMVSRSEELAKKVVTVNQFVVSNKTI--WSKPVFDEFEIKNYKDLLNNFRDFLDSLKAFNTPGKLRNFKYAEEELKEKFKTLETVKKIEKIIDFKNEVEELVKYLSSAEQQLPEEIELKQNINAMKNEVERFTKEIDNKESEDIKR-LTRELEELKIEYIDLYLEYHKKHRLDYNGDERKKKIMASDLFNNLKKLKDVGIFPVNKFDEIEKVLASLKTCYNFGKENIKTEVLCPNCGYSIKSGEVPVFGK--LDEIEDKIENLYKEWTKILLDNIEDPMIQERMEILNKDQQKVIRDFLNKKELPEKVDNLFVSAVKDLIAGLEKVEIEINEFISAITYDG-PVTVDEFKKRFLENVDFLIKGKDKDKVRIIIK     
4 Thit_1350      43.3%      -------MKYGDLIQYEPIETVIKLKDADKIDEAKRLV----KSYVVSEGMADSIINICIPQLQFDETLDNKG--IFIVGNYGTGKSHLMSVISAVAENK------EMLDYVSHEELKKEMGKIAGKFKVLRFD------------IGAVNTPLR------NIITKEIEKDLARYGIEFYFPPIDEVTNNKDAFMEMMSKFEDKFPDKGYLIVVDELLDF---LKARKEQELIRDLTFLREIGEITKSTRLRFMTGVQ----------------ETLFDNPAFNAVAQTVLKMK--DRFEQLI---IKREDISYVVSQRLLKK-NDRQKAWIRSHLEKF---SPLYKSISSR--IEEFVELYPIHPMFIEVFEKMF-----IVEKREVLKTISHLMRELLDKDVPEDEPGIISYDSYWKFLRDNPSLRAEPDIKRVVDKSIVVEDLIEHSFTRPQYKHAALRIVHALSVHRFTTGDIHTSVGITVENIKDDLCLYIKMPEIEEDFLITTIETIIKEIMKTL-----SWQYI--SYNPDNQQYYLDMVREGINYDAKIQEKAELL----SEDIFNRHYFELLIKVLDWNAPEKVPNMR---IWEYSLTWNEKNVKRYGYLFMGYPDERSTAQPPRDFYVYFLPP---FVEANYNKKYILNGKEDEVFFEFINADEEIIEKIKKYAAAMELSELSSSDQKKIYEDKAKGFQRDIT--KWIRDNVSKCFN----VSYKGETQSMIYWLKGKTANYDTIKSYIDEAASSCLSLYFSEKYSEYPTFYTKITEANLSEVFKSAMNYLAGK-KTETGKKVLQSFDLILGDDI-VPGNSKYA--NYFLNELYKLPPGKVLNREDIIENVNGEDIDKRFKLEVQWVVLLLSALVYSGDIILRIKNKVYDATTIEALANMNVGELIEFDSFERPRDIPVRELKTL---FTLLGLPSGLVTASLSKPEEAIRQMVAKSEELAKKVVTVNQFVVSNKTI--WGKPIFDEFEVRDYKNLLNSFSDFLDSLKAFNTPGKLRNFKYTEEELKEKFNILETVKKIEKIIDFKNEVEELVKYLASAEQQLPEEIELKQNINEMKNEVERFIKEIDTKESEDIKR-LTRELEELKIEYIKLYMEYHKKHRLDYNGDERKKKIMASDPFNNLKKLKDVGIFPVNKFDEIEKVLASLKTCYNFGKENIKTEVLCPNCGYSIKSDEVPVFGK--LDEIEDKIENLYKEWTKILLDNIEDPMIQERIEILNKDQQKAIRDFLNKKELPDKVDNLFVSSVKDLIAGLEKVEIEINEFISAITYDG-PVTVDEFKKRFLENVDFLIKGKDKDKVRIIIK     
5 Metvu_1289     11.4%      ----MQKLKVWEDVLDETLDMQVAPELGDVINKTAHKIYTNSEEFFKRTYFTDSMLQI-LDRLINTLSGKERHNIFLIYSLFGGGKTHTILTIYHAINNPNSLVNDETLKDYT-EDKKEKIKSIGLKLKDLQTQNIKILPIYGKGKLGQPSSPLNFGAYKVKTLWGYIGHCLGKYSIV--------ENDDKNLTVPDIETLRELLKGNKVVFLVDEIVHY---IDNLYNSGNEDDRRYAKNICKFFDTLSTALI-GTDSIMILTLPMEKDGEKVEKGYNKEIVLSLHRAVERVGGAELYSPLRTEGISGGEIVEILKKRIFEKIDDDFKEKIIEKYREIYSNTEIFGRF-----EESLSKTYPFHPDYIATLRTIVERGG-LQKTRDMVRITRIVIRSLLQEE--DLPTLIMPYHINPKNEKLRGILFGRNQVFADYGGAVLDVDLSAEKFKRFSKPELAEIILRYIFLKTYPY-----DSPIPLEGFPKKDTLARAVYEINF-FEKHALQ--LTDIINTINEIEKSSSFI--YLIKKDGIFWF---WRVANVSQMIESKKEELLTLNIVSVHKK--LEEFVKKFA-VEGRGLRTRR---IENNISFFKKSNIV--------------VSRDPQEF----------QDTEDYKLQILIRDDVDKSLLYRIIY--QYGTGTRTYRNTITVCYADKSI------DKLFEITARIMACDKVKGDIKAKYK-----SYGEEV------VQIQTSMVRSIEEDTKAEFDEFVASVFKKVA--YPK-DNDVEIVNATPTSKSILENVYSA--------------LIEWGKI--PKKLTFEGLEYYLNEV-------------------NITFNK------PIMFSELKSIIRTNTKLPFITDDQLKEAIKEGVKDLKIG-------IERDGRILFKRIHQSLPNYDEAGVPL----DDIKDTDIILPQIKALNKQINHILKEEKDEVVGNRYIKVWYEVYISEDESLPLRELVEETED---------------GFVVKPEFVDLVINGYIVRKTEEKIIGERNEFS-----LKLDRHNIEGKPGENVDVKVIITPLKGNDFEVN----------LEVDEGELDIDHGKVPYETTWHIKIPEAKKTYKIKAISED---GIVKTDKITLIPRTDIVEVHELSEDLKGGKLLEIRGIKS---SDDLNIIPENLNVKVRGI----------------------------LIIENDEHFKADFNNLSLDVVK----------YIIEEIEGVLDHKAMLDVDI-IFTEEIKIDD----------LIFEKLRCLNK-KAVFKIKKC--     
6 SiRe_0593      12.3%      MSNLIYENKVRDDVFNPSLDDQMAPELSDVIVGNAPQIYLDPKEFFSVTYITDSM-RILVNEITNALSQ-GKGITITIYSLFGGGKTHTLLLLYHTFNNP------KLVKEYG-LNVLEGVKVIGIGGKDSRTA-------------PSPVNPLKEDNVEIKTLWGYIAKKLGKYEIV--------RKLDEDMIAPQKDDLENLFKGEKVLILLDEIAYYLLRLKYRYKEYYEQCLLFLEALASMGVNLPVVLVATIPAKITTSSNKQDIIEYIESEYEPEVIKALAKRLERSG--KAFRAPI---ETSTDLANVLIKRIFKEVNETVKSNVVGKYQKL---TDQYKDYVNVAIAQDVVRTYPFHPLYIETLKKLLEGNTHLQGTREGIKITRYVIRDLWNSK--PTRSLILPSDLSIKNPQIHDLLLKDFKNYGTVADTII---------QRSKGLEIVFLLANYIFITTY-YHQLGLDAGQLASALPDDKEIITSVLDPEYLNLIGRLPSDVKEILGSISSNSKNVDMIIPYIMNDKGRYWV---TYFLDPKTICEKDASKVPQAEVEDRLDNIMLELAETPIDNVQKKGKKTISGLLLKLYRTILRNKNEL--------------VNVDEPSYYVVILSKPLCQDCKDVNEIFKASEEVARRILYYVPS--GKTEGLRRYSNTITLLFSSTGSNR----DKIEDYMRKHISCSNI--DVTPYYNDKISREYAGKI------------LREYLNSLENAIYNQIFQ-YFDKVA--YPIGNNEVRIVELKSGEKTLLQQVEST--------------LIDEGKIYREENFDFDVLVTLLSNL-------------------GIDITKK-----SFSVKDLREIFYTNPSLPFVTDSAIYNAIRNGVEKLEIG-------VMTKGKVYYKK-------YESMGE------IVVDESSIILPANEAADKEINELVSQEKTIEEDDKVIKRYYVLELPDGTRVPLRELKEDENWFV---------------KFNAGEIKLVEETLET--------GIE---------LYAEPKEIEGLPGEIKEVKIMVKKVGNFNSKVY----------LNSSYGELDVKEGIPDFQTTLKITLNQDGIT-----IVSARYDN--KEKRVEIVTRLRQSECEKVVDQVNRDSRISEIDIID---MSDIKTVIMKLNSSVIGK---KGLAGEI-------------NVEDP--NKKISVSVRPSGSNILDFIN-----------FINPILSLLGLKPKISGSLRIKVEEIKGIN----------KVEEINELINKGIIKVRVKVC--     
  consensus/90%             ........+hh-.l...sl-..ht.c.uDhhstst..l....cpah..phhs-ph.pl.hspl..s.s..t+t..hhIhu.aGsGKoHhh.hl.thhp........chhp.ht..thhct.t.IuhthKs.pht.............stss.sLp......phlht.ltcpLuphtl..........p.scp.hh..hpthpphh.spthlhllDElh.a...lc.hhpp....sh.ahctlsphh..h.hhhh.sh.................Et.ap..hh..ltptl.+.t..chap..h.....tt-ls.ll.pRlhcc.s-p.Kt.lht+hpch...o..atph......pphsthaPhHP.altshcphh.....l.tpR-hl+hhphhh+pLhppc.....shlhs.c...p..p.ps.hhtc.p.htshtts.l.........pR.ph..hs.hlhphl.lpph.h.....s.s..hpth.cc.plhh.h.-.p....httl...hp-Ihtol.....s.phI...h..cpt.aah...h..hs.pthhppctp.l......s.hpp..hc.h.p.ht.st..h..shp...l......hpppp.h..............ss.s..pa...........s..shp......tc.sc.hh.hl....th.pth+hatss.ph...spt.......sKh.t..tchh..p.l..slt.hap.....pYttth.............ht.lpp..p..hsphht.hFpchh..YPh....lp.hph..s.pphhp.l.ut..............Ll..scl...tp.pat...hhLspl...................s.php........h.h..Lttlhhoss.h..h.sp.h.ts.hptltph.lt.......h.p.tcl.ht........ap.hG........s.pp.p.hl.t..thscpl.chh.p.pp...tph.l..a....hsp.p.hsh+p.htp.p..................hht.t.lp...thh.s........s.t.........L..t.t.l.t..t...php.hhp.ltt...tl...........L.....ELc.p.h...hphph+hpls.sh.p.....h.pt...t..+.ttltlhsh.p.s-hpph.tplpts..ht..slhp....sphth...p.p..l.u................................cp..h.....tp...phlp...........hlp.l.thlshh.hlphph..hhptlt..s..........hh.-..p.l.+.h...+l+hh..